Ethyl orthoformate → HCID 22479013, compound

Participants

Reaction Steps

21.37 g (64.67 mmol) of 3-amino-4-[4-(tert-butoxycarbonylamino)butylamino]quinoline was heated at 100° C. in 43.0 ml (258.7 mmol) of triethyl ortho-formate and stirred for 5 hours. The reaction mixture was concentrated to dryness, triturated with diethyl ether, and collected by filtration to obtain 19.49 g (57.25 mmol) of 1-[4-(tert-butoxycarbonylamino)butyl]-1H-imidazo[4,5-c]quinoline shown below as faint yellowish white powder.

Provenance & Evidence