HCID 9798742, compound → 1-(4-aminobutyl)-1H-imidazo[4,5-c]quinolin-4-amine

Participants

Reaction Steps

One hundred ml of trifluoroacetic acid was added to 16.04 g (45.13 mmol) 1-[4-(tert-butoxycarbonylamino)butyl]-1H-imidazo[4,5-c]-quinoline-4-amine and the mixture was stirred overnight at room temperature. The reaction mixture was concentrated to dryness. A 2N sodium hydroxide solution aqueous solution (120 ml) was added thereto and the mixture was stirred. The precipitate thus formed was collected by filtration and washed with water and diethyl ether to obtain 9.64 g (37.76 mmol) of 1-(4-aminobutyl)-1H-imidazo[4,5-c]quinoline-4-amine shown below as a pale yellowish white solid. ##STR56## Its physicochemical properties were in agreement with those of the compound of Example 17.

Provenance & Evidence