HCID 18783946, compound → HCID 18783941, compound

Participants

Reaction Steps

2.50 g (6.33 mmol) of 4-[4-(tert-Butoxycarbonylamino)butylamino]-2-chloro-3-nitroquinoline was dissolved in 65 ml of methanol and 1 g of 10% palladium-carbon was added thereto. The mixture was stirred for one day under hydrogen atomosphere. The reaction mixture was filtered, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform:methanol=10:1 (v/v)). Finally, the resulting product was triturated with diethyl ether and collected by filtration to obtain 1.75 g (4.77 mmol) of 3-amino-4-[4-(tert-butoxycarbonylamino)butylamino]quinoline hydrochloride shown below as a yellow solid. ##STR57## Its spectroscopic data are as follows: IR (KBr) cm-1 : 3340, 2970, 1690, 1590, 1530, 1170.

Provenance & Evidence