1,1-Dimethylethyl 4-[4-[[[1-(2-methoxy-2-oxoethyl)-4-piperidinyl]carbonyl]amino]phenyl]-1-piperazinecarboxylate → HCID 15886541, compound

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Reaction Steps

A solution of Methyl 4-[[[4-(4-t-butyloxycarbonyl-1-piperazinyl)phenyl]amino]carbonyl]-1-piperidine acetate (2.1 g, 4.5 mmol) was treated with CH2Cl2 /TFA (10 mL/15 mL) for 20 min. Solution was concentrated and the residue was treated with MeOH/4M HCl (10 mL/10 mL). Solution was concentrated until precipitation started. Solution was filtered and the solid was washed with Et2O to give the title compound (1.5 g, 87%). MS (ES) m/e 361 [M+H]+. 1HNMR (250 MHz, DMSO[d6]) δ 1.4-4.5 (m, 22H), 6.9-9.5 (m, 5H). Anal. (C18H25N3O3.2.87HCl.0.5H2O) calcd: C, 54.32; H, 7.20; N, 10.29. found: C, 54.52; H, 7.24; N, 10.35.

Provenance & Evidence