HCID 18783783, compound → HCID 17047043, compound

HRID 1108668Notes

Reaction equation

HRID 1108668 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14](O)=[C:13]([N+]([O-])=O)[CH:12]=2)[CH2:7][CH2:6]1)=[O:4].C[N:24](C=O)C.CO>[Pd]>[F:1][C:2]([F:22])([F:21])[C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:24])=[CH:13][CH:12]=2)[CH2:7][CH2:6]1)=[O:4]

Participants

4

Reactant 2

HCID 18783783HCID 18783783, compoundHCID 21901440N,N-dimethylformamide methanol

Product 1

HCID 17047043HCID 17047043, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

To a solution of 4-(1-N-trifluoroacetyl-4-piperazinyl)nitrophenol (2.0 g, 6.6 mmol) in DMF/MeOH (20 mL/30 mL) was added 10% Pd/C (0.8 g). Solution was hydrogenated (45 psi) for 2 hr. Solution was filtered through Celite and the filtrate was concentrated to give the title compound (1.9 g, 100%). MS (ES) m/e 274 [M+H]+.

Workup

  1. customfor 2 hr
  2. filtrationSolution was filtered through Celite
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-d677f236747744e390fffb170bb46e9d
Source dataset
uspto-grants-2000_05
Patent number
US06069143

Reaction notes

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