反应详情

To a solution of 12.3 g (0.1 Mol) of p-Anisidine in 50 ml of ethanol, a solution of 17.4 g (0.1 Mol) of Dimethyl methoxymethylenemalonate in 70 ml of ethanol was added dropwise with stirring at room temperature. After an additional hour of stirring at that temperature, the reaction mixture was cooled with an ice bath and the product cristallised spontanously. The crude solid material was isolated by filtration and washed with ethanol and gave 12.9 g of the title product which is a white solid melting at 89-91° C., UV 328 nm (E=899).

1. stirringAfter an additional hour of stirring at that temperature
2. temperaturethe reaction mixture was cooled with an ice bath
3. customThe crude solid material was isolated by filtration
4. washwashed with ethanol