Cyclohexanecarboxaldehyde → HCID 44248498, compound

Participants

Reaction Steps

Reaction of p-methoxyphenylacetonitrile and cyclohexane-carboxaldehyde on a 20 mmol scale according to the procedure in Example 1, and two successive recrystallizations from chloroform/hexane gave 3.51 g of the desired anti-aldol product (68%), mp: 112.0-113.2° C. NMR (1H, 13C), IR, and Mass spectra were consistent with the assigned structure. Analysis: Calcd for C16H21NO2 : C, 74.10; H, 8.16; N, 5.40. Found: C, 74.25; H, 8.15; N, 5.39.

Provenance & Evidence