Methyl 4-(1-dimethylaminomethylene-2-oxopentyl)-3-nitrobenzoate → Methyl 3-nitro-4-(2-oxopentyl)benzoate

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Reaction Steps

A solution of methyl 4-(1-dimethylaminomethylene-2-oxopentyl)-3-nitrobenzoate (172 mg) in dioxane (9 ml) was refluxed for 4 days. The resulting mixture was evaporated in vacuo, and the residue was purified by thin layer chromatography with a mixture of hexane and ethyl acetate (2:1) to give methyl 3-nitro-4-(2-oxopentyl)benzoate (127 mg).

Provenance & Evidence