alpha-Bromo-o-chlorotoluene → HCID 22627345, compound

HRID 1108717Notes

Reaction equation

HRID 1108717 reaction equation
[C:1]([C:6]1[C:14]2[C:9](=[CH:10][C:11]([C:15]([O:17][CH3:18])=[O:16])=[CH:12][CH:13]=2)[NH:8][C:7]=1[CH2:19][CH2:20][CH3:21])(=[O:5])[CH:2]([CH3:4])[CH3:3].[Cl:22][C:23]1[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=1[CH2:25]Br>>[Cl:22][C:23]1[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=1[CH2:25][N:8]1[C:9]2[C:14](=[CH:13][CH:12]=[C:11]([C:15]([O:17][CH3:18])=[O:16])[CH:10]=2)[C:6]([C:1](=[O:5])[CH:2]([CH3:4])[CH3:3])=[C:7]1[CH2:19][CH2:20][CH3:21]

Participants

3

Reactant 2

HCID 11905alpha-Bromo-o-chlorotolueneHCID 22627360HCID 22627360, compound

Product 1

HCID 22627345HCID 22627345, compoundYield 84.5%

Procedure

Methyl 1-(2-chlorobenzyl)-3-isobutyryl-2-propylindole-6-carboxylate (533 mg) was prepare from methyl 3-isobutyryl-2-propylindole-6-carboxylate (440 mg) and 2-chlorobenzyl bromide (346 mg) in a similar manner to that of Example 1.

Sources & evidence

ORD record
ord-bee5906d9d2647df85a527576a65a174
Source dataset
uspto-grants-2000_05
Patent number
US06069156

Reaction notes

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