alpha-Bromo-o-chlorotoluene → HCID 22627187, compound

HRID 1108721Notes

Reaction equation

HRID 1108721 reaction equation
[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12](=[O:15])[CH2:13][CH3:14])=[CH:9][CH:8]=[C:7]([C:16]([O:18][CH3:19])=[O:17])[CH:6]=2)[CH3:2].[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23]Br>>[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[C:7]([C:16]([O:18][CH3:19])=[O:17])[CH:6]=2)[C:11]([C:12](=[O:15])[CH2:13][CH3:14])=[C:3]1[CH2:1][CH3:2]

Participants

3

Reactant 2

HCID 11905alpha-Bromo-o-chlorotolueneHCID 22627221Methyl 2-ethyl-3-(1-oxopropyl)-1H-indole-6-carboxylate

Product 1

HCID 22627187HCID 22627187, compound

Procedure

Methyl 1-(2-chlorobenzyl)-2-ethyl-3-propionylindole-6-carboxylate (278 mg) was prepared from methyl 2-ethyl-3-propionylindole-6-carboxylate (215 mg) and 2-chlorobenzyl bromide (0.24 ml) in a similar manner to that of Example 1.

Sources & evidence

ORD record
ord-546026d713994836b6af4784fbe987e7
Source dataset
uspto-grants-2000_05
Patent number
US06069156

Reaction notes

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