alpha-Bromo-o-chlorotoluene → HCID 10134596, compound

HRID 1108723Notes

Reaction equation

HRID 1108723 reaction equation
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:10]=2)[NH:5][C:4]=1[C:16](=[O:19])[CH2:17][CH3:18])[CH3:2].[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23]Br>>[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[C:8]([C:12]([O:14][CH3:15])=[O:13])[CH:7]=2)[C:3]([CH2:1][CH3:2])=[C:4]1[C:16](=[O:19])[CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 11905alpha-Bromo-o-chlorotolueneHCID 22627152HCID 22627152, compound

Product 1

HCID 10134596HCID 10134596, compound

Procedure

Methyl 1-(2-chlorobenzyl)-3-ethyl-2-propionylindole-6-carboxylate (66 mg) was prepared from methyl 3-ethyl-2-propionylindole-6-carboxylate (88 mg) and 2-chlorobenzyl bromide (0.051 ml) in a similar manner to that of Example 1.

Sources & evidence

ORD record
ord-7c00168f6ade438397d0b91d71fd21dc
Source dataset
uspto-grants-2000_05
Patent number
US06069156

Reaction notes

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