alpha-Bromo-o-chlorotoluene → HCID 22627144, compound

HRID 1108727Notes

Reaction equation

HRID 1108727 reaction equation
[CH2:1]([C:4]1[NH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[C:8]([C:13]([O:15][CH3:16])=[O:14])[CH:7]=2)[CH2:2][CH3:3].[Cl:17][C:18]1[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=1[CH2:20]Br>>[Cl:17][C:18]1[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=1[CH2:20][N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[C:8]([C:13]([O:15][CH3:16])=[O:14])[CH:7]=2)[CH:12]=[C:4]1[CH2:1][CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 11905alpha-Bromo-o-chlorotolueneHCID 22627295Methyl 2-propylindole-6-carboxylate

Product 1

HCID 22627144HCID 22627144, compoundYield 72.6%

Procedure

Methyl 1-(2-chlorobenzyl)-2-propylindole-6-carboxylate (400 mg) was prepared from methyl 2-propylindole-6-carboxylate (350 mg) and 2-chlorobenzyl bromide (364 mg) in a similar manner to that of Example 1.

Sources & evidence

ORD record
ord-741aae113e13428881a231ca48ec9c9e
Source dataset
uspto-grants-2000_05
Patent number
US06069156

Reaction notes

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