alpha-Bromo-o-chlorotoluene → HCID 86755425, compound

HRID 1108729Notes

Reaction equation

HRID 1108729 reaction equation
C([C:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([O:15][CH3:16])=[O:14])=[CH:10][CH:11]=2)[NH:6][C:5]=1[CH2:17][CH3:18])(=O)C.[Cl:19][C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1CBr>>[Cl:19][C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:16][O:15][C:13]([C:9]1[CH:8]=[C:7]2[C:12]([CH:4]=[C:5]([CH2:17][CH3:18])[NH:6]2)=[CH:11][CH:10]=1)=[O:14]

Participants

3

Reactant 2

HCID 11905alpha-Bromo-o-chlorotolueneHCID 22627420HCID 22627420, compound

Product 1

HCID 86755425HCID 86755425, compound

Procedure

Methyl 3-acetyl-1-((2-chlorobenzyl)-2-ethylindole-6-carboxylate (170 mg) was prepared from methyl 3-acetyl-2-ethylindole-6-carboxylate (100 mg) and 2-chlorobenzyl bromide (0.06 ml) in a similar manner to that of Example 1.

Sources & evidence

ORD record
ord-0917e70f7db64595a30f1eb4c7d00259
Source dataset
uspto-grants-2000_05
Patent number
US06069156

Reaction notes

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