反应详情

温度

50 °C

Acetic anhydride (1 ml) and pyridine (0.5 ml) were added to (trans)-3-(3-methoxyphenyl) cyclohexylamine (10 mg) and the mixture was stirred at 50° C. for 2 hours. The reaction solution was poured into glacial sodium bicarbonate water and extracted with ethyl acetate. The organic layer was washed with 1 N hydrochloric acid, saturated sodium bicarbonate water and saturated saline and dried with anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure to give 8 mg of N-acetyl-N-[3-(3-methoxyphenyl)cyclohexyl]amine (53.3%).

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with 1 N hydrochloric acid, saturated sodium bicarbonate water and saturated saline
3. dry with materialdried with anhydrous magnesium sulfate
4. distillationthe solvent was distilled off under reduced pressure