Bromomethyl 4-methoxyphenyl ketone → HCID 18784184, compound

Participants

Reaction Steps

After adding potassium tert-butoxide to a solution of ethyl acetoacetate (25.7 g) in benzene (420 ml) while cooling on ice, 4-methoxyphenacyl bromide (24.8 g) was gradually added and the mixture was refluxed for an hour. After allowing the reaction solution to cool, it was washed with 5% sodium hydroxide and purified water, and dried with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to give 26.2 g of ethyl 2-[2-(4-methoxyphenyl)-2-oxoethyl]-4-oxopentanoate (87.0% yield).

Provenance & Evidence