N-(2-Mercaptoethyl)-N'-methyl-2-nitro-1,1-ethenediamine → HCID 178482393, Verbindung

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The preparation of nizatidine by fusing 4-chloromethyl-2-dimethylaminomethylthiazole with N-(2-mercaptoethyl)-N'-methyl-2-nitro-1,1-ethenediamine has been suggested generically in EP 49618. However, we have found that N-(2-mercaptoethyl)-N'-methyl-2-nitro-1,1-ethenediamine cannot be isolated and stored. Our attempts to prepare this compound have always produced the disulphide, N-methyl-[N'-[2-(N"-methyl-2-nitro-1,1-ethenediamine)ethyldisulphanyl]ethyl]-2-nitro-1,1-ethenediamine and 3-methylamino-5,6-dihydro-[1,4]-thiazin-2-one oxime.

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