Methyl 3,4-Dimethoxybenzoate → N-(3,4-Dimethoxybenzoyl)-2-(3-methylphenyl) ethylamine

참여 물질

역할	이름	HCID	투입량
반응물	Methyl 3,4-Dimethoxybenzoate	HCID 16522	—
반응물	2-(3-Methylphenyl)ethan-1-amine	HCID 410085	—
용매	Dichloromethane	HCID 6344	—
생성물	N-(3,4-Dimethoxybenzoyl)-2-(3-methylphenyl) ethylamine	HCID 15068903	51%

반응 단계

A stirred solution of 2-(3-methylphenyl) ethylamine (28.3 g, 0.21 mol) and 36.9 g of methyl 3, 4-dimethoxybenzoate (36.9 g, 0.19 mol) was heated at 180° for 4 h. The crude amide was taken up in CH2Cl2 and washed with dilute HCl, dilute Na2CO3 and water. Chromatography over neutral alumina afforded 29 g (51%) of the title compound (one spot by tlc) eluted with CH2Cl2. The analytical sample showed mp 108°-109 after crystallization from i-PrOH.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	USRE034630
출처 데이터셋	uspto-grants-1994_06
ORD ID	ord-6dd328baf333427dbc68b8b470d564cd
출처 메모	uspto-grants-1994_06