Pyridine → HCID 178444512, compound

HRID 1108915Notes

Reaction equation

HRID 1108915 reaction equation
[CH2:1]([C@H:6]1[CH2:11][CH2:10][C@H:9]([C@H:12]2[CH2:17][CH2:16][C@H:15]([C:18](Cl)=[O:19])[CH2:14][CH2:13]2)[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].[F:21][C:22]([F:31])([F:30])[C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1.N1C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:1]([C@H:6]1[CH2:11][CH2:10][C@H:9]([C@H:12]2[CH2:13][CH2:14][C@H:15]([C:18]([O:29][C:26]3[CH:25]=[CH:24][C:23]([C:22]([F:30])([F:31])[F:21])=[CH:28][CH:27]=3)=[O:19])[CH2:16][CH2:17]2)[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

5

Reactant 3

HCID 1049PyridineHCID 678744-(Trifluoromethyl)phenolHCID 178444510HCID 178444510, compound

Product 1

HCID 178444512HCID 178444512, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of 29.3 g of trans-4-(trans-4-n-pentylcyclohexyl)-cyclohexanecarbonyl chloride in 120 ml of toluene is added dropwise in the course of 2 hours with stirring to a boiling solution of 16.2 g of p-trifluoromethylphenol and 10 ml of pyridine in 120 ml of toluene. The reaction mixture is mixture is refluxed for a further 3 hours and then evaporated. The residue is worked up as conventional. p-Trifluoromethylphenyl trans-4-(trans-4-n-pentylcyclohexyl)-cyclohexanecarboxylate is obtained.

Workup

  1. temperatureis refluxed for a further 3 hours
  2. customevaporated

Sources & evidence

ORD record
ord-767af8969e254519b6528aabbd52f018
Source dataset
uspto-grants-1994_06
Patent number
US05318721

Reaction notes

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