HCID 19021158, compound → HCID 19021147, compound

Participants

Reaction Conditions

Reaction Steps

In a 50 ml-round-bottomed flask, 19 g of polyphosphoric acid, 0.30 g (1.55 mM) of 2-amino-4-hexylphenol and 0.37 g (1.58 mM) of 4-octylbenzoate acid were placed, followed by stirring for 3.5 hours at about 250° C. After the reaction, the reaction mixture was poured into water to precipitate a crystal. The crystal was recovered by filtration and was washed with 10% K2CO3. The crystal was dissolved in ethyl acetate and washed with water, followed by drying with anhydrous sodium sulfate and distilling-off of the solvent. The resultant residue was purified by silica gel column chromatography (eluent: toluene/hexane=1/2) to obtain 0.17 g of 2-(4-octylphenyl)-5-hexylbenzoxazole (yield: 28.0%). ##STR72##

Provenance & Evidence