2-{p-[(3,5-Dichloro-2-pyridyl)oxy]phenoxy}propionaldehyde → Sodium 2-{p-[(3,5-dichloro-2-pyridyl)oxy]phenoxy}-1-hydroxy-1-propanesulfonate

Participants

Reaction Steps

A solution of 2-{p-[(3,5-dichloro-2-pyridyl)-oxy]phenoxy}propionaldehyde (25.38 g, 0.0813 mol) in methanol (300 mL) is added dropwise to a solution of sodium bisulfite (10.2 g, 0.0976 mol) in water (100 mL). The reaction mixture is stirred for 4 days at room temperature and filtered. The filter cake is dried in a vacuum oven overnight to obtain the title product as a white solid (24.6 g, mp 172°-173° C.).

Provenance & Evidence