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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1108974Generated: October 26, 2026

Dimethylformamide → 1-phenyl-8-fluoro-3-(1H-1,2,4-triazol-1-yl-methyl)-2-(1H)quinolone

https://huagongshe.com/reaction/1108974

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
Reactant1-phenyl-8-fluoro-3-bromomethyl-2(1H)-quinoloneHCID 19021638—
ReactantHCID 178507080HCID 178507080—
Product1-phenyl-8-fluoro-3-(1H-1,2,4-triazol-1-yl-methyl)-2-(1H)quinoloneHCID 19021628—

Reaction Steps

Following the procedure of example 22, react 8-fluoro-1-phenyl-3-bromomethyl-2(1H)-quinolone with sodium triazole in dimethylformamide. Chromatograph to obtain the major product, 1-phenyl-8-fluoro-3-(1H-1,2,4-triazol-1-yl-methyl)-2-(1H)quinolone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05318971
Source datasetuspto-grants-1994_06
ORD IDord-1d306289d47d404b8bef78abbf7022cd
Source noteuspto-grants-1994_06