Ammonia → HCID 15223039, compound

Participants

Reaction Steps

Small pieces of sodium (~230 mg) are added to a solution of Example 1 (2 g, 6.5 mmol) in freshly distilled ammonia until the blue color persists. The reaction mixture is quenched with a small amount of solid ammonium chloride and allowed to evaporate off excess ammonia. The residue is taken up in 25 mL of water and the pH is adjusted to 7.0 with 18% HCl. This is extracted with methylene chloride (3×50 mL). The organic extracts are combined, dried over MgSO4 and concentrated in vacuo. Recrystallization from methanol and ether (1+19) affords the title compound.

Provenance & Evidence