HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1109031Generated: October 26, 2026
Sulfuric Acid → N5-benzyloxycarbonyl-ornithine, t-butyl ester
https://huagongshe.com/reaction/1109031
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | H-Orn(Z)-OH | HCID 7009570 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | tert-Butyl acetate | HCID 10908 | — |
| Product | N5-benzyloxycarbonyl-ornithine, t-butyl ester | HCID 7019766 | — |
Reaction Steps
Suspend N5 -benzyloxycarbonyl-ornithine (80 g, 0.3 mol) in t-butyl acetate (250 mL) and cool to 10° C. Add p-toluenesulfonic acid (57 g, 0.3 mol) and add, by dropwise addition, concentrated sulfuric acid (80 mL). Stir at 10° C. until the reaction is complete, basify to pH 8 by adding a suspension of sodium bicarbonate in water. Extract with ethyl acetate, dry (MgSO4), and evaporate to give N5 -benzyloxycarbonyl-ornithine, t-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05318992 |
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| Source dataset | uspto-grants-1994_06 |
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| ORD ID | ord-45555e6d55c24eb3af47a6ec852f723c |
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| Source note | uspto-grants-1994_06 |
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