Barium hydroxide, octahydrate → HCID 19708157, compound

HRID 1109034Notes

Reaction equation

HRID 1109034 reaction equation
C([NH:6][NH:7][CH2:8][CH2:9][CH:10]1[NH:14]C(=O)N[C:11]1=[O:16])(OCC)=O.[OH2:17].O.O.O.O.O.O.O.[OH-].[Ba+2].[OH-]>O>[NH2:14][CH:10]([CH2:9][CH2:8][NH:7][NH2:6])[C:11]([OH:16])=[O:17]

Participants

4

Reactant 2

HCID 17749109Barium hydroxide, octahydrateHCID 67642181HCID 67642181, compound

Product 1

HCID 19708157HCID 19708157, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Mix 5-[(2-(carbethoxyhydrazino)-ethyl)]-hydantoin (2.3 g, 10 mmol), barium hydroxide octahydrate (18.15 g, 10 mmol) and water (55 mL). Reflux for 12 hours, remove the white solid by filtration, extract the filter cake with boiling water (25 ml) and finally wash with hot water (25 mL). Combine the filtrate and washings, treat with ammonium carbonate (5.7 g) and heat with stirring. Filter off the barium carbonate, wash the filter cake with hot water and evaporate the filtrate and washings in vacuo to give 2-amino-4-hydrazino-butanoic acid.

Workup

  1. temperatureReflux for 12 hours
  2. customremove the white solid
  3. filtrationby filtration
  4. extractionextract the filter cake with boiling water (25 ml)
  5. washfinally wash with hot water (25 mL)
  6. additionCombine the filtrate and washings, treat with ammonium carbonate (5.7 g)
  7. temperatureheat
  8. filtrationFilter off the barium carbonate
  9. washwash the filter cake with hot water
  10. customevaporate the filtrate and washings in vacuo

Sources & evidence

ORD record
ord-a9a63d320c6f4829a622ebfe5f627a3c
Source dataset
uspto-grants-1994_06
Patent number
US05318992

Reaction notes

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