Ethyl Acetate → HCID 86747907, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentyl]-1-heptanamine (4.35 g; 0.01 mol) and pyridyltosylurea (3.2 g; 0.011 mol; Frigola Conatansa, Jordi; ES 534,782) in diphenyl ether (35 mLs) was stirred under nitrogen at 180° C. for 30 minutes. The cooled solution was chromatographed with 1:1 hexane:ethyl acetate to give the title compound (4.03 g; 0.0073 mol) as an orange oil. 1H NMR (CDCl3) δ 8.15-8.05(m, 1H), 7.9(d, 1H, J=8.4 Hz), 7.6-7.4(m, 5H), 7.3-7.1 (m, 8H), 6.9-6.8 (m, 1H), 3.32 (t, 2H, J=7.2 Hz), 3.25(t,2H, J=7.9 Hz), 3.05(t,2H, J=6.6 Hz), 1.8-1.45(m,8H), 1.4-1.2(m, 8H), 0.9(t,3H, J=6.8 Hz).

Provenance & Evidence