HRID1109153

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10176127

Pyridine hydrochloride

C5H6ClN

反应SMILES：COc1cccc2c1CC[C@H]1[C@@H]2CCN1CCCCCCN1C(=O)CC(C)(C)CC1=O

HCID131718496

未命名化合物

PRODUCTS

产物

反应SMILES：CC1(C)CC(=O)N(CCCCCCN2CC[C@@H]3c4cccc(O)c4CC[C@@H]32)C(=O)C1

HCID131718497

未命名化合物

收率 89%

PROCEDURE

实验过程

In an analogous manner to that described in Example 20b), from 9.2 g (21.56 mmol) of rac-cis-1-[6-(6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indol-3-yl)-hexyl]-4,4-dimethyl-piperidine-2,6-dione using pyridine hydrochloride there were obtained 7.9 g of (89%) rac-cis-1-[6-(6-hydroxy-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indol-3-yl)hexyl]-4,4-dimethylpiperidine-2,6-dione; yellowish crystals of m.p. 98.5°-99° after crystallization from ether/hexane.