HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Dibucaine IMpurity D
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Butyl 2-butoxy-4-quinolinecarboxylate | HCID 11779624 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Dibucaine IMpurity D | HCID 10014750 | 90% |
Reaction Steps
A mixture of 2.67 g (8.86 mmols) of Compound b, 1.77 g of sodium hydroxide, 60 ml of water and 60 ml of dioxane was stirred at room temperature for an hour. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluting solvent: chloroform/methanol=5/1) to give 1.91 g (yield 90%) of Compound a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05319085 |
| Source dataset | uspto-grants-1994_06 |
| ORD ID | ord-4801f70a26024351b36c888027d16128 |
| Source note | uspto-grants-1994_06 |