Water → HCID 131718505, compound

HRID 1109235Notes

Reaction equation

HRID 1109235 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][C:7](=O)[CH:8]2[CH2:13][C:14]([O:16]CC)=O.[CH:20]1([NH2:25])[CH2:24][CH2:23][CH2:22][CH2:21]1.O>C1(C)C=CC=CC=1>[CH:20]1([N:25]2[C@@H:7]3[C@@H:8]([C:9]4[CH:10]=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[C:4]=4[CH2:5][CH2:6]3)[CH2:13][C:14]2=[O:16])[CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

5

Reactant 3

HCID 962WaterHCID 2906CyclopentylamineHCID 12541369HCID 12541369, compound

Product 1

HCID 131718505HCID 131718505, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

4.0 g (0.01525 mol) of ethyl 1,2,3,4-tetrahydro-5-methoxy-2-oxo-1-naphthylacetate were dissolved in 80 ml of toluene, 3.0 ml (0.0305 mol) of cyclopentylamine were added thereto and the mixture was boiled for 40 hours on a water separator. After concentration the residue was hydrogenated with 1.2 g of Raney-nickel in 500 ml of ethanol at 120° and 140 bar for 10 hours. The product was chromatographed over silica gel with cyclohexane/ether 1:1. There were obtained 2.0 g (46%) of rac-cis-3-cyclopentyl-1,3,3a,4,5,9b-hexahydro-6-methoxy-2H-benzo[e]indol-2-one as white crystals with m.p. 84°-88°.

Workup

  1. concentrationAfter concentration the residue
  2. customwas hydrogenated with 1.2 g of Raney-nickel in 500 ml of ethanol at 120°
  3. customThe product was chromatographed over silica gel with cyclohexane/ether 1:1

Sources & evidence

ORD record
ord-b975afc68ca74697ae2414dad1852f28
Source dataset
uspto-grants-1994_06
Patent number
US05318967

Reaction notes

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