Acetic Anhydride → HCID 54344336, compound

HRID 1109295Notes

Reaction equation

HRID 1109295 reaction equation
[OH:1][NH:2][C:3]([N:5]1[CH2:9][CH2:8][C:7](=[CH:10][C:11]2[CH:16]=[C:15]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:14]([OH:21])=[C:13]([C:22]([CH3:25])([CH3:24])[CH3:23])[CH:12]=2)[C:6]1=[O:26])=[O:4].[C:27](OC(=O)C)(=[O:29])[CH3:28]>N1C=CC=CC=1>[C:27]([O:1][NH:2][C:3]([N:5]1[CH2:9][CH2:8][C:7](=[CH:10][C:11]2[CH:16]=[C:15]([C:17]([CH3:18])([CH3:19])[CH3:20])[C:14]([OH:21])=[C:13]([C:22]([CH3:25])([CH3:24])[CH3:23])[CH:12]=2)[C:6]1=[O:26])=[O:4])(=[O:29])[CH3:28]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 54201704HCID 54201704, compound

Product 1

HCID 54344336HCID 54344336, compoundYield 60.5%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-(N-Hydroxycarbamoyl)-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-one (Ia-4) (2 g, 5.55 mmole), acetic anhydride (680 mg, 6.66 mmole), and pyridine (10 ml) were reacted according to the same method as in Example 22, whereby 1.35 mg of the objective compound (Ia-17) was obtained in 60.5% yield. Mp.: 165°-166° C.

Sources & evidence

ORD record
ord-39da97c375bc4ec79b59796810c78ec5
Source dataset
uspto-grants-1994_06
Patent number
US05319100

Reaction notes

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