3-Bromopyrrolidin-2-one → HCID 19022166, compound

HRID 1109303Notes

Reaction equation

HRID 1109303 reaction equation
[Br:1][CH:2]1[CH2:6][CH2:5][NH:4][C:3]1=[O:7].[CH3:8][N:9]([CH3:20])[N:10](C1C=CC=CC=1)[C:11](=O)[O-:12]>N1C=CC=CC=1>[Br:1][CH:2]1[CH2:6][CH2:5][N:4]([C:11](=[O:12])[NH:10][N:9]([CH3:20])[CH3:8])[C:3]1=[O:7]

Participants

4

Reactant 2

HCID 101034713-Bromopyrrolidin-2-oneHCID 86747910HCID 86747910, compound

Product 1

HCID 19022166HCID 19022166, compoundYield 63.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Substantially in the same manner as in Example 39 (1), 8.2 g (50 mmol) of 3-bromopyrrolidin-2-one and 9.91 g (55 mmol) of N-dimethylaminophenylcarbamate in 100 ml of pyridine were treated to give 7.96 g of the objective compound as white crystal in 63.6% yield.

Sources & evidence

ORD record
ord-ec5c1c9931a54139a7e0f63e9e2a46ad
Source dataset
uspto-grants-1994_06
Patent number
US05319100

Reaction notes

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