HCID 178498896, compound → HCID 178429728, compound

HRID 1109339Notes

Reaction equation

HRID 1109339 reaction equation
[SH:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[CH:10][C:11]([C:12]([O:14]C)=[O:13])=[C:4]2[N:3]=1>[OH-].[Na+]>[SH:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=[O:13])=[C:4]2[N:3]=1

Participants

3

Reactant 1

HCID 178498896HCID 178498896, compound

Product 1

HCID 178429728HCID 178429728, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

7.20 g of methyl 5-mercapto-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate were heated to 100° in 2N sodium hydroxide solution until almost all had dissolved. The solution was cooled, filtered and the filtrate was adjusted to pH 2. The product was filtered off under suction, washed with water and acetone and dried. There was obtained 5-mercapto-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid of m.p. 225° (dec.).

Workup

  1. dissolutionall had dissolved
  2. temperatureThe solution was cooled
  3. filtrationfiltered
  4. filtrationThe product was filtered off under suction
  5. washwashed with water and acetone
  6. customdried

Sources & evidence

ORD record
ord-f1a6f5926f3a45128a1ae5f9a59799ab
Source dataset
uspto-grants-1994_06
Patent number
US05319140

Reaction notes

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