HCID 178429728, compound → HCID 178429727, compound

HRID 1109340Notes

Reaction equation

HRID 1109340 reaction equation
[SH:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[CH:10][C:11](C(O)=O)=[C:4]2[N:3]=1>C(=O)([O-])O.[K+]>[CH3:8][C:6]1[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=[C:2]([SH:1])[CH:7]=1

Participants

3

Reactant 1

HCID 178429728HCID 178429728, compound

Product 1

HCID 178429727HCID 178429727, compound

Reagents, catalysts & solvents 1

HCID 516893Potassium BicarbonateSolvent

Procedure

2.00 g of 5-mercapto-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid were heated to 220° under argon for 1 hour. After cooling, the reaction mixture was taken up in 10 percent potassium hydrogen carbonate solution. The insoluble portion was filtered off under suction and taken up in water. The solution was acidified to pH 2 and the precipitate was filtered off under suction. After drying, there was obtained 7-methylpyrazolo[1,5-a]pyrimidine-5-thiol.

Workup

  1. temperatureAfter cooling
  2. filtrationThe insoluble portion was filtered off under suction
  3. filtrationthe precipitate was filtered off under suction
  4. customAfter drying

Sources & evidence

ORD record
ord-2fe847ded61c4d0dbd1db0c74a2a0d2c
Source dataset
uspto-grants-1994_06
Patent number
US05319140

Reaction notes

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