Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 12884453 | HCID 12884453 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 145805292 | HCID 145805292 | — |
Reaction Steps
A solution of 17.5 g of 2-(tritylamino)-4-thiazoleglyoxylic acid ethyl ester (Z)-O-(2-bromoethyl) oxime and 5 g of sodium azide in 200 ml of N,N-dimethylformamide was stirred at 50° C. for 15 hours. The reaction solution was cooled to 20° C. and partitioned between ethyl acetate and water. The organic phase was dried over sodium sulphate and the solvent was removed in a vacuum. Crude 2-(tritylamino)-4-thiazoleglyoxylic acid ethyl ester (Z)-O-(2-azido-ethyl) oxime was obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05319140 |
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| Source dataset | uspto-grants-1994_06 |
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| ORD ID | ord-b11841b4eb2247f7a2ea1e9dfb9a251f |
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| Source note | uspto-grants-1994_06 |
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