HCID 53913940, compound → HCID 54427475, compound

Participants

Reaction Steps

The reaction liquid was poured into water, and extracted with methylene chloride. The methylene chloride layer was washed with a diluted hydrochloric acid and water in this order. The organic layer thus recovered was distilled under a reduced pressure to remove the solvent, and subjected to purification by a silica gel chromatography (n-hexane:ethyl acetate=10:2) to obtain 2.1 g of p-nitrobenzoic acid 1,1,1-trifluoro-2-decyl ester. The ester was dissolved in 30 ml of ethanol, to which 0.21 g of 5 % Pd-C catalyst was added, and the solution was stirred overnight under hydrogen atmosphere, then the Pd-C catalyst was separated by filtration, and the ethanol was distilled off under a reduced pressure to obtain 2.0 g of p-amino-benzoic acid 1,1,1-trifluoro-2-decyl ester which was the desired compound of the reaction [1].

Provenance & Evidence