HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1109466Generated: November 1, 2026
Hydrochloric Acid → Ethyl 2-(5-benzylthio-2-nitrophenoxy)acetate
https://huagongshe.com/reaction/1109466
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzyl mercaptan | HCID 7509 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 2-(5-fluoro-2-nitrophenoxy)acetate | HCID 13752803 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-(5-benzylthio-2-nitrophenoxy)acetate | HCID 18994386 | 68% |
Reaction Steps
A mixture of ethyl 2-(5-fluoro-2-nitrophenoxy)acetate (11 benzylmercaptan (5.2 g), triethylamine (5.08 g) and DMF (50 ml) was stirred and heated to 80° C. for 7 hours. The mixture was cooled, poured into water and acidified by the addition of dilute aqueous hydrochloric acid. The mixture was extracted with diethyl ether. The organic phase was washed with water and with brine, dried (MgSO4) and evaporated to give ethyl 2-(5-benzylthio-2-nitrophenoxy)acetate (10.6 g, 68%) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05321025 |
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| Source dataset | uspto-grants-1994_06 |
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| ORD ID | ord-5372794114d141a98d27ea7e5b3a1bc4 |
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| Source note | uspto-grants-1994_06 |
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