4-(Methylamino)benzoic acid → HCID 19020604, compound

HRID 1109473Notes

Reaction equation

HRID 1109473 reaction equation
[CH3:1][NH:2][C:3]1[CH:25]=[CH:24][C:6]([C:7]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[CH2:11][CH2:10]2)=[O:8])=[CH:5][CH:4]=1.CNC1C=CC(C(O)=O)=CC=1>>[ClH:23].[CH3:1][NH:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([N:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][C:17]3[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=3)[CH2:13][CH2:14]2)=[O:8])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 663454-(Methylamino)benzoic acidHCID 19020574HCID 19020574, compound

Product 1

HCID 19020604HCID 19020604, compound

Procedure

1-[4-(N-methylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine can be prepared from 3 g of p-(N-methylamino)benzoic acid in a manner analogous to that described in Example 1. 1-[4-(N-methylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine hydrochloride having a melting point of 156°-158° is obtained therefrom by treatment with a solution of hydrogen chloride in ethyl acetate.

Sources & evidence

ORD record
ord-117d849a1be44d3a8755188f1bdeee50
Source dataset
uspto-grants-1994_06
Patent number
US05321027

Reaction notes

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