Methyl iodide → HCID 19020583, compound

HRID 1109474Notes

Reaction equation

[C:1]([NH:4][C:5]1[CH:27]=[CH:26][C:8]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)[CH2:13][CH2:12]2)=[O:10])=[C:7]([Cl:28])[CH:6]=1)(=[O:3])[CH3:2].[CH3:29]I>>[C:1]([N:4]([C:5]1[CH:27]=[CH:26][C:8]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]3[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=3)[CH2:13][CH2:12]2)=[O:10])=[C:7]([Cl:28])[CH:6]=1)[CH3:29])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 19020618HCID 19020618, compound

Product 1

HCID 19020583HCID 19020583, compound

Procedure

0.8 g of 1-[4-(N-methylamino)-2-chlorobenzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine (see Example 8) is methylated in a manner analogous to that described in Example 5 with 0.3 g of methyl iodide to form 1-[4-(N-acetyl-N-methylamino)-2-chlorobenzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine. It has a melting point of 162°-163°.

Sources & evidence

ORD record: ord-8fc78775d08c4963a42700e83dcf9b2e
Source dataset: uspto-grants-1994_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05321027

Reaction notes

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