Methyl iodide → HCID 19020625, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 5, 5 g of 1-[3-methyl-4-(N-acetylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine are methylated with 0.8 g of methyl iodide to form 1-[4-(N-acetyl-N-methylamino)-3-methylbenzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine and converted into the hydrochloride having a melting point of 195°.

Provenance & Evidence