Methyl iodide → HCID 19020584, compound

HRID 1109478Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:25]=[C:24]([NH:26][C:27]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[O:28])[CH:23]=[CH:22][C:4]=1[C:5]([N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[CH2:9][CH2:8]1)=[O:6].[CH3:37]I>>[ClH:2].[Cl:2][C:3]1[CH:25]=[C:24]([N:26]([C:27]([O:29][CH2:30][C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)=[O:28])[CH3:37])[CH:23]=[CH:22][C:4]=1[C:5]([N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([Cl:21])=[CH:19][CH:20]=2)[CH2:9][CH2:8]1)=[O:6]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 19020590HCID 19020590, compound

Product 1

HCID 19020584HCID 19020584, compound

Procedure

In a manner analogous to that described in Example 5, the 1-[2-chloro-4-(N-benzyloxycarbonylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine hydrochloride obtained in accordance with Example 17 is methylated with 0.8 g of methyl iodide, yielding 1-[2-chloro-4-(N-benzyloxycarbonyl-N-methylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine hydrochloride.

Sources & evidence

ORD record: ord-aab81d87af284fc68384817760bce9be
Source dataset: uspto-grants-1994_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05321027

Reaction notes

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