Sodium Hydroxide → HCID 19020760, compound

Participants

Reaction Steps

30 ml of 1N aqueous solution of sodium hydroxide was added to a suspension of Compound 1 (3.0 g) according to Example 1 in acetone (60 ml), and the mixture was heated under reflux for 16 hours with stirring. After cooling, the acetone was removed by evaporation under reduced pressure and the resulting residue was diluted with water and extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure to give 1.90 g (87.6%) of 1,2-di-(4-methoxyphenyl)-4-(2-pyrrolyl)-1,4-butanedione (Compound 10).

Provenance & Evidence