Morpholine → HCID 14652026, compound

Participants

Reaction Steps

1.40 g of morpholine was added to a solution of 3.00 g of 3-(2,3-epoxypropoxy)-4-methyl-5-phenylisoxazole (prepared as described in Preparation 3) in 50 ml of ethanol, and the mixture was heated under reflux for 3 hours. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure, and the resulting solid residue was recrystallized from diethyl ether, to give 3.75 g (yield 90.7%) of the title compound as a colorless powder, melting at 94°-95° C.

Provenance & Evidence