Methyl iodide → 1-Methyl-1-[2-(2-propylcarbamoyl-10-phenothiazinyl)propyl]pyrrolidinium iodide

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Reaction Steps

A solution of N-propyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide, L series (1.1 g), and methyl iodide (0.75 cc) in acetone (40 cc) is stirred for 2 days at a temperature in the region of 20° C. The pale yellow solution thereby obtained is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C. and the light cream-colored meringue-like residue is suspended with stirring for 30 minutes in diethyl ether (50 cc), drained, washed with diethyl ether (3×10 cc) and dried at 40° C. under reduced pressure (5 mm Hg; 0.7 kPa). 1-Methyl-1-[2-(2-propylcarbamoyl-10-phenothiazinyl)propyl]pyrrolidinium iodide, L series (1.2 g), is thereby obtained in the form of a light beige solid, m.p. 155°-160° C.

Provenance & Evidence