Methyl iodide → HCID 19020542, compound

Participants

Reaction Steps

A solution of N-(3-methylbutyl)-10-[1-(1-pyrolidinyl)-2-propyl]-2-phenothiazinecarboxamide, L series (1.5 g), and methyl iodide (0.94 cc) in acetone (50 cc) is stirred for 4 days at a temperature in the region of 20° C. The light yellow solution obtained is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C., and the light cream-colored meringue-like residue is suspended with stirring for 10 minutes in diethyl ether (100 cc), drained, washed with diethyl ether (2×10 cc) and dried at 40° C. under reduced pressure (5 mm Hg, 0.7 kPa). 1-Methyl-1-{2-[2-(3-methylbutyl)carbamoyl-10-phenothiazinyl]propyl}-pyrrolidinium iodide, L series (1.55 g) is thereby obtained in the form of a light beige powder, m.p. about 125°-130° C., the NMR spectrum of which is identical to that of the product of Example 11.

Provenance & Evidence