HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutylmethylamine → N-cyclobutylmethyl-10-[(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutylmethylamine | HCID 409746 | — |
| Reactant | 10-[1-(1-Pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxylic acid hydrochloride | HCID 14536640 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-cyclobutylmethyl-10-[(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide | HCID 15096214 | 46.4% |
Reaction Steps
Using a procedure similar to that described in Example 15, but starting with 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxylic acid hydrochloride (3.4 g) in dichloromethane (100 cc) and cyclobutylmethylamine (4.5 g), and after recrystallization in isopropyl ether, N-cyclobutylmethyl-10-[(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide (1.7 g) is obtained in the form of white crystals, m.p. 133° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05321026 |
| Source dataset | uspto-grants-1994_06 |
| ORD ID | ord-c065d544c9b34dc595841d7de44bb2dd |
| Source note | uspto-grants-1994_06 |