Acetic Acid → HCID 20074870, compound

Participants

Reaction Steps

The procedure is as described in Example 17, but starting with N-allyl-10-[1-(2,5-dihydro-1-pyrrolyl)-2-propyl]-2-phenothiazinecarbothioamide, L series (1.49 g), in acetic acid (25 cc) and a solution of mercuric acetate (1.16 g) in acetic acid (25 cc). The yellow meringue-like residue (1.27 g) is purified by chromatography on a column (height: 23 cm; diameter: 2.6 cm) of silica gel (0.04-0.63 mm) under a slight excess pressure of nitrogen (40 kPa), eluting with ethyl acetate (1.5 liters) and collecting 25-cc fractions. Fractions 10 to 58 are combined and concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C. to give N-allyl-10-[1-(2,5-dihydro-1-pyrrolyl)-2-propyl]-2-phenothiazine-carboxamide, L series (0.45 g), in the form of a yellow resin.

Provenance & Evidence