Hydrochloric Acid → HCID 15925353, compound

Participants

Reaction Steps

A 3N solution (3 cc) of hydrochloric acid in isopropyl ether is added dropwise in the course of 5 minutes to a solution of N-(2-methylbenzyl)-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide, L series (3.2 g), in ethyl acetate (25 cc). The solution is concentrated to dryness at 50° C. under reduced pressure (30 mm Hg; 4 kPa) to give a solid, which is taken up in isopropyl ether (20 cc). It is then drained washed with isopropyl ether (3×5 cc) and dried under reduced pressure (5 mm Hg; 0.7 kPa) at 40° C. to give N-(2-methylbenzyl)-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide hydrochloride, L series (2.4 g), in the form of a yellow solid, m.p. approximately 125° C.

Provenance & Evidence