Fumaric Acid → HCID 15096223, compound

Participants

Reaction Conditions

Reaction Steps

Fumaric acid (0.7 g) and mercuric acetate (2.5 g) are added in the course of 20 minutes to a solution of N-(2-methylbenzyl)-10[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbothioamide, L series (3.8 g) in acetic acid (30 cc), and the mixture obtained is stirred for 12 hours at a temperature in the region of 20° C. The black suspension obtained is filtered on sintered glass plugged with Celite and the yellow filtrate is concentrated under reduced pressure (30 mm Hg; 4 kPa) at 40° C. The residue is taken up with ethyl acetate (100 cc) and the organic phase is washed successively with normal sodium hydroxide (2×20 cc) and distilled water (2×20 cc) and with saturated aqueous sodium chloride solution (20 cc) and dried over magnesium sulphate. After filtration, the yellow filtrate is concentrated under reduced pressure (30 mm Hg; 4 kPa) at 40° C. and N-(2-methylbenzyl)-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide, L series (3.2 g), is thereby obtained in the form of a yellow oil, which is used subsequently without further treatment.

Provenance & Evidence