HCID 19020966, compound → HCID 19020977, compound

Participants

Reaction Steps

Dissolved in 20 ml of ethyl acetate were 500 mg (1.39 mmol) of 1-(3,4-methylenedioxyphenyl)-4-(3,4,5-trimethoxyphenyl)butan-1-ol, followed by the addition of 5 mg of palladium chloride. The resulting mixture was stirred at room temperature for 15 hours under a hydrogen atmosphere of 1 atm. Insoluble matter was removed by filtration and the filtrate was then concentrated. The concentrate thus obtained was purified by column chromatography (silica gel: "MERCK #9385", 50 g, eluent: 1:5 mixed solvent of ethyl acetate and hexane), whereby 388 mg of the title compound were obtained as colorless oil (yield: 81%).

Provenance & Evidence