Formaldehyde → HCID 15324506, compound

Participants

Reaction Steps

To a stirred solution of 4.5 g (23 mmol) of 2-tert-butyl-4-mercapto-6-methylaniline and 3.9 g (23 mmol) of diphenylamine in 30 mL of methanol at -5° C. is added 0.9 g (23 mmol) of formaldehyde as a 37% aqueous solution (1.9 mL). The reaction mixture is stirred for 72 hours at room temperature and then is heated for 5 hours at 50°-55° C. The solvent is removed in vacuo and the residue is purified by flash column chromatography (silica gel, 9:1, heptane:ethyl acetate eluent) to give 3.9 g (45%) of the title compound as a colorless liquid.

Provenance & Evidence