反应详情

A mixture of 6.30 g of 8-(3,4-difluorophenyl)-1,4-dioxaspiro[4.5]decane, 60 ml of toluene and 40 ml of formic acid was stirred for 18 hours. The formic acid phase was separated and extracted twice with 30 ml of toluene each time. The combined toluene phase was washed neutral with water, dried over sodium sulphate and concentrated. There were obtained 5.00 g of 4-(3,4-difluorophenyl)cyclohexanone as a colourless oil.

1. customThe formic acid phase was separated
2. extractionextracted twice with 30 ml of toluene each time
3. washThe combined toluene phase was washed neutral with water
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated