Toluene → HCID 15020049, compound

HRID 1109689Notes

Reaction equation

HRID 1109689 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:18][CH2:17][C:12]3(OCC[O:13]3)[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[F:8].C1(C)C=CC=CC=1>C(O)=O>[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:10][CH2:11][C:12](=[O:13])[CH2:17][CH2:18]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 1140TolueneHCID 19019250HCID 19019250, compound

Product 1

HCID 15020049HCID 15020049, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of 6.30 g of 8-(3,4-difluorophenyl)-1,4-dioxaspiro[4.5]decane, 60 ml of toluene and 40 ml of formic acid was stirred for 18 hours. The formic acid phase was separated and extracted twice with 30 ml of toluene each time. The combined toluene phase was washed neutral with water, dried over sodium sulphate and concentrated. There were obtained 5.00 g of 4-(3,4-difluorophenyl)cyclohexanone as a colourless oil.

Workup

  1. customThe formic acid phase was separated
  2. extractionextracted twice with 30 ml of toluene each time
  3. washThe combined toluene phase was washed neutral with water
  4. dry with materialdried over sodium sulphate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-f9bde76fa01442b78b139358ca8f1a65
Source dataset
uspto-grants-1994_06
Patent number
US05322638

Reaction notes

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